The Transformation of Burnet's Immune Surveillance Cells into Natural Killer Cells and its Circumstances

Sinkovics Joseph Geza, Horvath Joseph Csaba
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Abstract

by accidental misprint, instead of monocytoid noted as “macrophagic” in the legends. These new cells appeared clearly distinct from the already well known compact T cells (Figure 1), as a different new population (Figure 2), since their cytoplasm displayed fine round unstained white granulation. These larger rounded up lymphoid cells were cytotoxic to tumor cells; compare with hundreds of detailed complex pictures produced in the following years. This chapter also showed the tetraploid fused cells that have become later the first “hybridomata”, natural or artificially produced. The large granulated lymphoid cells we soon referred to as “Burnet’s Immune Surveillance Cells” and held them *Corresponding author: Joseph Geza Sinkovics, Retired Medical Director, the Cancer Institute, St. Joseph’s Hospital, Tampa FL, USA CaSe RepoRt
伯内特免疫监视细胞向自然杀伤细胞的转化及其情况
由于偶然的印刷错误,在图例中将单核细胞标记为“巨噬细胞”而不是单核细胞。这些新细胞明显不同于已知的致密T细胞(图1),作为一个不同的新群体(图2),因为它们的细胞质显示出未染色的细圆形白色肉芽。这些较大的聚集淋巴样细胞对肿瘤细胞具有细胞毒性;与随后几年里制作的数百幅详细复杂的图片相比。本章还展示了后来成为第一个“杂交瘤”的四倍体融合细胞,无论是自然的还是人工产生的。我们很快将大颗粒状淋巴细胞称为“伯内特免疫监视细胞”并保存它们*通讯作者:Joseph Geza Sinkovics,退休医学主任,癌症研究所,圣约瑟夫医院,坦帕FL,美国病例报告
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