Synthesis, Characterization and Anti-Cancer Activity of gold (III) and Nickel (II) Metal Ion Complexes Derived from Tetrazole-Triazole Compound

Abstract

This research is for academic understanding to work out new ligand behavior4-({(5-(4-hydroxyphenyl)-3-sulfanyl-1H-1,2,4-triazol-1-yl)amino}(1H-tetrazol-5-yl)methyl)-2-methoxyphenol (L) with gold (III) and nickel (II) metal ions. Ligand (L) has been synthesized from cyclization of the interaction of (4-hydroxy-3-methoxyphenyl){[5-(4-hydroxyphenyl)-3-sulfanyl-1H-1,2,4-triazol-1-yl]amino}acetonitrile (F) with sodium azide. α-Amino nitrile compound (F) intern synthesized from interaction of aldehyde amine and KCN acidic medium as three components one put reaction. The presence of well oriented donor atoms (N2-type) of ligand (L) interacted with gold (III) and nickel (II) ions under reflux to prepare [1:2] [M:L]Cl electrolytic complexes, the complexes [Au (L)3]Cl3and [Ni (L)2]Cl2were suggested to have square planar geometry. The resulting products were characterized via technical1H-NMR, UV-Vis, IR spectroscopy, conductivity and EDX. The cytotoxic effect was studied on a breast cancer cell line (MCF-7 cell line). At different concentrations for both complexes. The results showed that gold(III) complex has higher cytotoxicity than nickel(II) complex against cancer cell line.