Effect of Process Parameters on the critical attributes of the Liposomal formulations

Abstract

This study investigate the effect of processparameters on the size, distribution, zeta potential  and loading efficiency for the co-delivery of liposomalformulation of Ran-RCC1 inhibitory peptide (RANIP) and doxorubicin (DOX) tobreast cancer. The results showthat drug concentration, pH and ultrasound intensity are all critical factors tocontrol the attributes of the liposomes.