Synthesis Of Chiral Allylic Amines Via Palladium(0) Catalysed Allylations Of Allylic Carbonates With Chiral Sulfinamide Anions

Abstract

The palladium(0) catalysed allylation reactions of allylic carbonates with chiral sulfinamide anions to give unstable allylic sulfinamide products are described. These products are readily converted to stable, chiral N-benzoyl or N-tosyl allylic amine derivatives with poor to modest enantiomeric purities (ee 23-41%).