A serotonergic, midbrain-raphe model of tonic immobility

Abstract

Research involving the effects of serotonergic and other pharmacological manipulations on tonic immobility is reviewed. An attempt is made to show how these findings parallel independent research involving precursor availability and drug-induced changes in the electrical activity of raphe neurons. Central serotonergic neuronal mechanisms appear to play a crucial role in modulating tonic immobility.