THE EFFECTS OF CARVEDILOL AND Q10 ON ISOPRENALINE-INDUCED CARDIOTOXICITY: ELECTROCARDIOGRAPHIC, BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION IN RATS.

Al-Azhar Journal of Pharmaceutical Sciences Pub Date : 2016-09-01 DOI:10.21608/ajps.2018.6640

N. Elshourbagy

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引用次数: 2

Abstract

Objective: To assess the therapeutic effect of combining of Carvedilol and Q10 on electrocardiographic, biochemical and histopathological changes in isoprenaline induced myocardial infarction. Methods: Myocardial infarction was induced in rats by subcutaneous (s.c) injection of isoprenaline (85mg/kg) for two consecutive days at an interval of 24 h. Rats were treated orally (p.o) with Carvedilol at dose (5 mg/kg/day) and Q10 at dose (10 mg/kg/day) for a period of 14 days. At the end of experiment electrocardiographic, biochemical and histopathological changes were monitored from control and experimental groups. Results: ISP intoxicated rats showed a significant tachycardia , elevation ST and prolongation of QTc (i.e. ST, QTc & HR) due to conduction abnormalities, increased serum creatine kinase isoenzyme-MB (CK-MB) Treatment with Carv+Q10 significantly improved the ISP induced alteration in ECG, biochemical and histopathological changes. Conclusions: The present result shows that treatment with Carv+Q10 significantly attenuates myocardial infarction in ISPintoxicated rats.

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卡维地洛和q10对异丙肾上腺碱诱导的大鼠心脏毒性的影响:心电图、生化和组织病理学评价。

目的:评价卡维地洛联合辅酶Q10对异丙肾上腺素所致心肌梗死的心电图、生化及病理组织学改变的影响。方法:连续2天皮下注射异丙肾上腺素(85mg/kg)诱导大鼠心肌梗死，间隔24 h。大鼠口服卡维地洛(5mg/kg /d)和辅酶Q10 (10mg /kg/d)，连续14天。实验结束时，观察对照组和试验组大鼠心电图、生化及组织病理学变化。结果:ISP中毒大鼠由于传导异常出现明显的心动过速、ST升高和QTc(即ST、QTc和HR)延长，血清肌酸激酶同工酶- mb (CK-MB)升高。Carv+Q10治疗可显著改善ISP诱导的心电图、生化和组织病理学改变。结论:Carv+Q10可显著减轻ispintoxig大鼠心肌梗死。

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Al-Azhar Journal of Pharmaceutical Sciences

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