Preparation of Deferasirox in nano-scale by ultrasonic irradiation and optimization the amount and reaction time parameters

Abstract

This work reports a facile sonochemical route in the synthesis of nano particle of deferasirox for the first time. One application of nanotechnology is in improvement of available treatments for various diseases. Deferasirox (ICL670 or Exjade) is a tridentate chelating agent for removing transfusion overload iron in thalassemia patients. In the present work, deferasirox was prepared in nano size by using of ultrasound waves. The effects of amount and reaction time on the size of deferasirox were investigated. These parameters were optimized at various amounts and different reaction times. Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) studies show that the deferasirox in nature structure does not change during the reaction. The results show that the finest particle is related to the following conditions: 45min, time reaction and 0.1g, amount of deferasirox. Therefore, the ultrasonic bath method has a fundamental role in the preparation of deferasirox in nano scale. This method is simple, relatively fast and low cost.