Immunoglobulin G Levels in Neonates After Receiving Phototherapy

IF 0.4 4区 医学 Q4 PEDIATRICS
K. Mirnia, M. Saeedi, Razieh Sangsari, Fatemeh Mokhtarian Zavareh, Vahideh Mirnia, N. Rezaei
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引用次数: 0

Abstract

Background: Most cases of newborn hyperbilirubinemia are physiologic; however, excessive unconjugated bilirubin is a potential neurotoxin. Phototherapy treats moderate to severe hyperbilirubinemia in addition to severe jaundice. If phototherapy increases immunoglobulin G (IgG) clearance, there is a chance of humoral immune disorders. Objectives: The purpose of the study was to investigate the effect of phototherapy on the level of IgG in neonates. Methods: This study investigated 40 full-term newborns with hyperbilirubinemia. Blood samples were taken before and 72 hours after phototherapy. The IgG level was measured by calorimetry tests. Results: Phototherapy resulted in a decrease in IgG levels. The IgG level significantly decreased from 833.135 to 720.185 mg/dL. Before phototherapy, 12.5% of the population had low IgG levels; however, 32.5% had low IgG levels after the treatment. Conclusions: According to the results of the study, intensive phototherapy caused a reduction in IgG levels. Since there was no significant decrease in IgG levels in neonates who received conventional phototherapy, it can be concluded that this treatment is safe in terms of IgG levels.
新生儿光疗后免疫球蛋白G水平的变化
背景:大多数新生儿高胆红素血症是生理性的;然而,过量的非共轭胆红素是一种潜在的神经毒素。除了严重黄疸外,光疗还可治疗中度至重度高胆红素血症。如果光疗增加免疫球蛋白G (IgG)的清除,则有可能出现体液免疫紊乱。目的:探讨光疗对新生儿血清IgG水平的影响。方法:对40例足月新生儿高胆红素血症进行调查。在光疗前和光疗后72小时采集血样。用量热法测定IgG水平。结果:光疗后血清IgG水平明显降低。IgG水平由833.135 mg/dL显著降低至720.185 mg/dL。光疗前,12.5%的人群IgG水平较低;32.5%的患者治疗后IgG水平较低。结论:根据研究结果,强化光疗引起IgG水平降低。由于接受常规光疗的新生儿IgG水平没有明显下降,因此可以得出结论,就IgG水平而言,这种治疗是安全的。
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来源期刊
CiteScore
0.90
自引率
20.00%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.
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