Point-of-Care Testing in Hypercoagulable Conditions Managed With Warfarin

Nicholas N. Faber, Shanaya C. Bulmer, Mona A. Gandhi, Angela K. Nagel
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Abstract

Purpose The aim of this review was to summarize new data on the use of international normalized ratio (INR) point-of-care testing (POCT) devices in hypercoagulable disease states such as antiphospholipid syndrome (APS) and those with left ventricular assist devices (LVADs). Methods PubMed and Google Scholar were searched for keywords relating to warfarin, point-of-care testing, and hypercoagulable conditions. Intensive care unit studies and articles not in English were excluded. Results Four recent studies examining 3 different POCT devices in patients with APS and 2 for patients with LVADs were found. The studies compared devices against laboratory INRs as a standard or against another POCT device to determine device agreeability or bias. Results showed that CoaguChek XS does not correlate well with laboratory INRs in patients with APS but is acceptable in LVAD patients. Coagsense and ProTime InRhythm correlated well with laboratory INR values in APS patients. Conclusions Coagsense and ProTime InRhythm may be acceptable POCT devices to use for APS patients, whereas CoaguChek XS is not acceptable. In LVAD patients, CoaguChek XS is acceptable because it correlates well with laboratory INR values.
华法林治疗高凝状态的即时护理试验
本综述的目的是总结在高凝疾病状态(如抗磷脂综合征(APS))和具有左心室辅助装置(lvad)的患者中使用国际标准化比率(INR)点护理试验(POCT)装置的新数据。方法在PubMed和Google Scholar中检索与华法林、即时检测和高凝状态相关的关键词。非英文的重症监护病房研究和文章被排除在外。结果最近有4项研究对3种不同的POCT装置用于APS患者,2种用于lvad患者。这些研究将设备与实验室INRs作为标准或与另一种POCT设备进行比较,以确定设备的亲和性或偏差。结果显示,CoaguChek XS与APS患者的实验室inr相关性不佳,但在LVAD患者中是可以接受的。APS患者的凝血和ProTime InRhythm与实验室INR值相关性良好。结论用于APS患者的POCT装置可接受为coagulsense和ProTime InRhythm,而CoaguChek XS则不可接受。在LVAD患者中,CoaguChek XS是可以接受的,因为它与实验室INR值有很好的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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