Molecular genetic analysis of CYP2D6 and HLA-B*15:02 in Thai autistic spectrum disorder children: Implication for pharmacogenetics testing and optimization of drug treatments
P. Suwannarat, M. Chamnanphon, Nattawat Ngamsamut, Ananya Sinrachatanant, Bhunnada Chamkrachchangpada, Teerarat Tan-kam, A. Puangpetch, C. Sukasem, P. Limsila
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引用次数: 5
Abstract
Genetic polymorphisms of CYP2D6 and HLA-B have been associated with efficacy and toxicity variation of various antipsychotic drugs including those for autistic spectrum disorders (ASD). The objective of this study is to investigate and compare allele frequency of CYP2D6 between 79 Thai ASD patients and 154 non-ASD by using microarray technique, and of HLA-B*15:02 between 292 Thai ASDs patients and 627 non-ASDs by using PCRSSOP based method. The most common allele frequency of CYP2D6*10, *1 and *2 in ASD group were 54.43% (86/158), 22.78% (36/158) and 11.39% (18/158), respectively, and nonASD were 44.18% (138/308), 26.30% (81/308) and 7.47% (23/308), respectively. The frequencies of HLA-B*15:02 in ASD and nonASD were 14.72% (43/292) and 14.19%
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