Correlation of Carotid Artery Intima-Media Thickness with Age, Body Mass Index and Glomerular Filtration Rate in Chronic Kidney Disease Patients

Q4 Medicine

Medicine Today Pub Date : 2021-11-07 DOI:10.3329/medtoday.v33i2.56062

A. Kaiser, R. Islam, M. Mozaffor, S. Feroz, Md Mustafizur Rahman

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Abstract

Introduction: Ultrasound measurements of the intima media thickness (IMT) in the carotid arteries is a strong predictor for cardiovascular events both in the general and diseased population. Materials & Methods: This cross-sectional analytic study was conducted to observe correlation of CIMT with age, body mass index (BMI) and glomerular filtration rate (GFR) in chronic kidney disease (CKD). The study was done in Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, on 80 chronic kidney disease patients, from July 2014 to June 2015. All the biochemical parameters were measured according to the standard laboratory techniques. Body mass index (BMI) was calculated by person’s body weight divided by height. Glomerular filtration rate (GFR) was calculated using the modification of diet in renal disease (MDRD) formula. CIMT measurement was done by duplex study of carotid vessels through high resolution B-mode ultrasound. Results: Mean age of the patients was 36.1±9.5 years. 20 (25%), 26 (32.5%) and 34 (42.5%) patients were in CKD stage 3, 4 and 5 respectively. Age, serum creatinine and GFR showed statistically significant difference among stage 3, 4 and 5 CKD patients (p<0.001). However, no difference was evident in BMI and mean CIMT among stage 3, 4 and 5 CKD patients. Significant positive correlations were found between age and CIMT (r=+0.332; p=0.003) and BMI and CIMT (r=+0.294; p=0.008). However, no significant correlation was evident with estimated glomerular filtration rate (eGFR) and CIMT (r=–0.181; p=0.109). Conclusion: Age, serum creatinine and estimated glomerular filtration rate showed statistically significant difference among different stages of CKD patients (stage 3, 4 and 5). There were significant positive correlations found in between age and CIMT as well as BMI and CIMT in chronic kidney disease patients, with an exception to GFR and CIMT. Medicine Today 2021 Vol.33(2): 147-151

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慢性肾病患者颈动脉内膜-中膜厚度与年龄、体重指数及肾小球滤过率的相关性

超声测量颈动脉内膜中膜厚度(IMT)是普通人群和患病人群心血管事件的有力预测指标。材料与方法:通过横断面分析研究，观察慢性肾脏疾病(CKD)患者CIMT与年龄、体重指数(BMI)、肾小球滤过率(GFR)的相关性。该研究于2014年7月至2015年6月在孟加拉国达卡的Bangabandhu Sheikh Mujib医科大学(BSMMU)肾内科对80名慢性肾病患者进行了研究。所有生化指标均按标准实验室技术进行测定。身体质量指数(BMI)是用人的体重除以身高来计算的。肾小球滤过率(GFR)采用肾脏疾病饮食修正(MDRD)公式计算。CIMT测量是通过高分辨率b超对颈动脉血管的双工研究完成的。结果:患者平均年龄36.1±9.5岁。CKD 3期20例(25%)，4期26例(32.5%)，5期34例(42.5%)。3期、4期、5期CKD患者年龄、血清肌酐、GFR差异有统计学意义(p<0.001)。然而，3期、4期和5期CKD患者的BMI和平均CIMT无明显差异。年龄与CIMT呈显著正相关(r=+0.332;p=0.003)、BMI和CIMT (r=+0.294;p = 0.008)。然而，肾小球滤过率(eGFR)和CIMT之间没有明显的相关性(r= -0.181;p = 0.109)。结论:年龄、血清肌酐、肾小球滤过率在CKD不同分期(3期、4期、5期)之间差异有统计学意义。慢性肾病患者年龄与CIMT、BMI、CIMT呈显著正相关，但GFR、CIMT除外。医学今日2021卷33(2):147-151

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Medicine Today Medicine-Medicine (all)

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