The Effects of Green Apple Juice (Pyrus malus L.) on Cholesterol Levels in Guinea Pig (Cavia cobaya)

Abstract

The chemical compound content of green apple juice was pactin, which wass a group of polysaccharides that can lower cholesterol levels. In addition, there were also several secondary metabolites, including flavonoids, glycosides and triterpenoids. To determine the effect of giving green apple juice on the blood cholesterol levels of guinea pigs treated with hypercholesterolemia by giving food mixed with 15% European chicken egg yolk, 15% goat fat, 20 grams of feed for 6 days. The study was divided into 5 groups (A, a, b, c and S) measured cholesterol levels, group A was given aquadest orally (negative control), groups a, b, c were given green apple juice orally at a dose of 2.03 grams / kg BW, dose 4.06 gram / kg BW, 6.09 gram / kg BW, group S was given 0.01% simvastatin suspension at a dose of 0.775 mg / kg BW orally as a positive control for 14 days. Based on the results of the research tested using statistics, it was obtained that the administration of green apple juice at a dose of 2.03 grams / kg BW, a dose of 4.06 grams / kg BW, a dose of 6.09 grams / kg BW showed that the reduction in cholesterol levels was not significantly different from giving simvastatin 0 suspension. 01% dose 0.775mg / kg BW / day.