Evaluation of microcrystalline cellulose modifed from alpha-cellulose obtained from Costus afer

Journal of Pharmaceutical and Allied Sciences Pub Date : 2011-02-08 DOI:10.4314/JOPHAS.V7I5.63465

U. Ajali, O. Okorie, U. Odoh

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Abstract

Alpha cellulose was obtained from Costus afer and part of it was modified to microcrystalline cellulose (CAMCC). The physicochemical properties of the microcrystalline cellulose were determined and compared with those of commercial microcrystalline cellulose (Avicel 101). The swelling capacity, hydration capacity, loss on drying, true, bulk and tapped densities were 36.0 %, 5.47 %, 1.00 %, 1.198 g/ml, 0.271 g/ml, and 0.342 g/ml for CAMCC and 25.0 %, 5.10 %, 0.80 %, 1.21 g/ml, 0.291 g/ml and 0.387 g/ml respectively for Avicel 101. The CAMCC had no organic impurities, starch, and dextrins and was soluble in tetramine copper dihydroxide. It is an odourless, white, tasteless powder which conformed to the standard specification for microcrystalline cellulose. From the physicochemical properties CAMCC can act as a good disintegrant in tablet and granule formulations. Costus afer can be a good source of alpha-cellulose for pharmaceutical applications Keywords : Costus afer , alpha-cellulose, microcrystalline cellulose, physicochemical properties, phytochemical analysis Journal of Pharmaceutical and Allied Sciences , Vol. 7 No. 5 (2010)

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木香树α -纤维素改性微晶纤维素的研究

从木香树中提取α纤维素，并将其部分改性为微晶纤维素(CAMCC)。测定了微晶纤维素的理化性质，并与市售微晶纤维素(Avicel 101)进行了比较。CAMCC的溶胀量、水化量、干燥损失量、真密度、堆积密度和疏通密度分别为36.0%、5.47%、1.00 %、1.198 g/ml、0.271 g/ml和0.342 g/ml, Avicel 101的溶胀量、水化量和疏通密度分别为25.0%、5.10%、0.80%、1.21 g/ml、0.291 g/ml和0.387 g/ml。CAMCC不含有机杂质、淀粉和糊精，可溶于二氢氧化铜。本品为无臭、白色、无味粉末，符合微晶纤维素的标准规范。从理化性质看，CAMCC在片剂和颗粒制剂中均可作为良好的崩解剂。关键词:木香，α -纤维素，微晶纤维素，理化性质，植物化学分析医药与相关科学杂志，Vol. 7 No. 5 (2010)

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Journal of Pharmaceutical and Allied Sciences

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