Investigation of the Global Trend of Thyroid Cancer Incidence and Its Relationship with the Prevalence of Type 2 Diabetes: An Application of Longitudinal Random Effects Regression Model

IF 0.4 Q4 ONCOLOGY

International Journal of Cancer Management Pub Date : 2022-09-11 DOI:10.5812/ijcm-120720

Maryam Rezaei Gazaki, Mohsen Askari Shahi, R. Malboosbaf, S. Jambarsang

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引用次数: 0

Abstract

Background: In recent years, the incidence of thyroid cancer has been increasing. On the other hand, those with insulin resistance often have higher thyroid volume and a risk of developing thyroid nodules. Objectives: The objective of this study was to investigate the global trend of thyroid cancer and its relationship with the prevalence of type 2 diabetes. Methods: The information in the present study is related to the prevalence of type 2 diabetes and the incidence of thyroid cancer in all countries of the world, which was extracted from the Global Burden of Disease site during 1990 - 2019. In order to investigate the relationship between the prevalence of type 2 diabetes and the incidence of thyroid cancer, a longitudinal random effects regression model was used with both random effects of intercept and the slope of the regression line. Results: The results showed that the risk of developing thyroid cancer associated with diabetes was 0.00024 (95% CI 0.00023 - 0.00025), 24 persons per 100000. This significance level was also evaluated separately in men and women, so that the relative risk in men was estimated to be 0.00018 (95% CI 0.00017 - 0.00019) and in women equal to 0.00033 (95% CI 0.00031 - 0.00035). Conclusions: Findings showed that type 2 diabetes can be a risk factor for thyroid cancer. So that this effect can be considered on both men and women and is more intense in women than men.

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甲状腺癌全球发病率趋势及其与2型糖尿病患病率关系的研究:纵向随机效应回归模型的应用

背景:近年来，甲状腺癌的发病率呈上升趋势。另一方面，那些有胰岛素抵抗的人往往有更高的甲状腺体积和发展甲状腺结节的风险。目的:本研究的目的是调查甲状腺癌的全球趋势及其与2型糖尿病患病率的关系。方法:本研究的数据来源于1990 - 2019年全球疾病负担网站(Global Burden of Disease site)，与世界各国2型糖尿病患病率和甲状腺癌发病率相关。为了探讨2型糖尿病患病率与甲状腺癌发病率之间的关系，采用纵向随机效应回归模型，随机效应为截距和回归线斜率。结果:结果显示，患甲状腺癌合并糖尿病的风险为0.00024 (95% CI 0.00023 - 0.00025)，每10万人24人。该显著性水平在男性和女性中也分别进行了评估，因此男性的相对风险估计为0.00018 (95% CI 0.00017 - 0.00019)，女性的相对风险为0.00033 (95% CI 0.00031 - 0.00035)。结论:研究结果表明，2型糖尿病可能是甲状腺癌的危险因素。因此，这种影响对男性和女性都有影响，而且女性比男性更强烈。

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来源期刊

International Journal of Cancer Management ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.