Diagnosis of Breast Cancer by some remarkable enzymes

Abstract

Objectives: This study aimed to evaluate the activity of several remarkable enzymes in the serum of breast cancer and estimate their  potential value in the diagnosis of breast cancer.Methods: The study comprised of 70 patients with  breast cancer and 50 age and sex-matched healthy subjects as controls. Levels of (5 –Nucleotidase), Acid phosphatase activity (ACP), Glutamate dehydrogenase (GDH), Serum β-glucuronidase, Aldehyde dehydrogenase (ALDH), Alcohol Dehydrogenase (ADH), Superoxide dismutase (SOD) and Adenosine deaminase ADA were measured  using enzymatic methods.Results: There was a significant increase in the Catalytic activities of 5 –Nucleotidase((p<0.001), ACP ( p< 0.05), GDH ( ≤0.001 p), Serum β-glucuronidase (p<0.0001), ADH ( p< 0.001), SOD (p< 0.001))and ADA(p< 0.001),while there was no significant increase in the level of Aldehyde dehydrogenase (ALDH)( p = 0.231)in sera of breast cancer patients compared to the control.Conclusion: The present study strongly indicates the potential role of SOD, GDH, ADH, GDH,5–Nucleotidase,GLU and ACP as important biomarkers in breast cancer.