A primer on ageing studies in mice: Considerations, opportunities and limitations

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2018-03-01 DOI:10.1016/j.ddmod.2019.01.002

Paul K. Potter

引用次数: 0

Abstract

One of the major challenges currently facing health care providers is an ageing population that is spending more time in ill-health. Many ageing individuals have multiple and complex needs which affect the ability to treat them effectively, which also has a significant impact on their own independence and quality of life. There are many aspects of testing interventions to improve health in old age in pre-clinical models; from breeding strategies to measurements of outcomes. Here we provide a brief overview of the major considerations to take into account in such studies and the limitations or challenges we face in these studies.

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小鼠衰老研究的入门:考虑、机会和限制

卫生保健提供者目前面临的主要挑战之一是人口老龄化，健康状况不佳的时间越来越长。许多老年人有多种复杂的需求，影响到有效治疗他们的能力，这也对他们自己的独立性和生活质量产生重大影响。在临床前模型中，有许多方面的测试干预措施可以改善老年人的健康;从育种策略到测量结果。在这里，我们简要概述了在这些研究中需要考虑的主要因素以及我们在这些研究中面临的限制或挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.