Electrochemical Sensor for Acetaminophen Based on a Poly(diphenylamine sulfonic acid) Modified Sensor

Abstract

A sensitive and simple modified sensor was prepared by electrodeposition of diphenylamine sulfonic acid (DPSA) to the glassy carbon electrode surface by cyclic voltammetry (CV) technique. The electrooxidation of Acetaminophen (AC) was accomplished by CV and differential pulse voltammetry at poly(DPSA) modified sensor. As a result of the findings, the current values were enhanced and both substances were separated at the modified sensor compared to the bare electrode. There was linearly between the oxidation current and concentration of AC from 0.0 to 100 μM in phospate buffer solution at pH 7.0. The limit of detection was 3.0 nM and the sensitivity was 0.4108 μA/μM. The determination of AC was successfully and satisfactorily carried out in real samples such as human blood serum and urine at the poly(DPSA) sensor. To the best knowledge of this work, this is the first study that detect the AC in the presence of ascorbic acid at poly(DPSA) sensor in the literature.