TSLP contributes to allergic airway inflammation induced by diesel exhaust particle exposure in an experimental model of severe asthma

Abstract

Numerous epidemiologic studies have reported associations between exposure to air pollutant and increased risk of allergic diseases, with a recent study estimating that 8-20% of asthma emergency room visits worldwide could be attributed to ozone exposure and 4-9% to exposure to particulate matter smaller than 2.5µm (PM2.5 ). Traffic pollution derived diesel particles represent a major source of PM2.5 in large urban centers and have been linked to increased susceptibility to asthma development and asthma exacerbations.