Synthesis and Characterization of Biphasic Calcium Phosphate Substituted Cerium as a Potential Osteoporotic Bone Filler

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-28 DOI:10.3311/ppch.21111

T. Windarti, L. Nulandaya, Widjijono Widjijono, N. Nuryono

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Abstract

Biphasic calcium phosphate substituted cerium (BCP/Ce) is a potential material for osteoporotic bone filler. Synthesis of BCP/Ce was conducted by the sol-gel method. This work aimed to study the influence of cerium as a precursor on the crystal structures, surface properties, and agglomeration of BCP/Ce. A series of samples were prepared by various Ce percentages (0.5–16%) and a constant molar ratio of (Ca + Ce)/P = 1.2. A structural study by Rietveld refinement calculation confirmed that synthesis without Ce produced BCP that contained hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) at a ratio of 93:7. The presence of Ce increased β-TCP content to 73% for the use of Ce 8%. None of Ca in the HA structure was replaced by Ce. Otherwise, Ce replaced Ca in β-TCP structure by isomorphic substitution at the Wyckoff site of 6a (0,0,-0.085) or Ca (4) position. As the maximum occupancy of Ca (4) = 43%, about 17% of that was substituted by Ce for the use of 14% Ce. Ce was found in two states as Ce3+ and Ce4+ ions with Ce3+/Ce4+ ratio > 1. The presence of Ce on the particle surface caused a change in the particle shape, from plate-like to spherical. The particle size decreased to <100 nm with the increase of Ce content. The rise of Ce content in BCP decreased the luminescent property due to the increase of oxygen vacancies. The negative value of Zeta potential confirms that BCP/Ce surface can accommodate bone cell proliferation.

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双相磷酸钙取代铈作为潜在骨质疏松性骨填料的合成与表征

双相磷酸钙取代铈(BCP/Ce)是一种潜在的骨质疏松性骨填充材料。采用溶胶-凝胶法制备了BCP/Ce。本工作旨在研究作为前驱体的铈对BCP/Ce的晶体结构、表面性质和团聚的影响。在(Ca + Ce)/P = 1.2的恒定摩尔比下，以不同的Ce含量(0.5 ~ 16%)制备了一系列样品。Rietveld精化计算的结构研究证实，不含Ce的合成得到的BCP含有羟基磷灰石(HA)和β-磷酸三钙(β-TCP)，比例为93:7。Ce的存在使β-TCP含量增加到73%，而Ce用量为8%。HA结构中的Ca没有被Ce取代。在β-TCP结构中，Ce在6a(0,0，-0.085)或Ca(4)位置的Wyckoff位点同构取代了Ca。当Ca(4)的最大占用率为43%时，约17%的Ca(4)被Ce取代，而14%的Ce被Ce所利用。Ce以Ce3+和Ce4+两种形态存在，Ce3+/Ce4+的比值为bbbb1。Ce在颗粒表面的存在引起颗粒形状的变化，从板状变为球形。随着Ce含量的增加，颗粒尺寸减小到<100 nm。BCP中Ce含量的增加会导致氧空位的增加，从而降低其发光性能。Zeta电位的负值证实了BCP/Ce表面可以促进骨细胞增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.