РЕТРОСПЕКТИВНЫЙ АНАЛИЗ ПРИЧИН ЛЕТАЛЬНОСТИ У БОЛЬНЫХ С ТЯЖЕЛЫМ ТЕЧЕНИЕМ COVID-19

IF 0.2 Q4 ANESTHESIOLOGY
S. Sereda, S. Dubrov, M. Denysiuk, O. Kotliar, S. Cherniaiev, Y. Zaikin, T. Baranovska, O. Havrylenko, V. Borisova, G. Ponyatovska
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引用次数: 1

Abstract

In Ukraine, more than 3.5 million cases of COVID-19 have been registered during the pandemic, and the death toll is almost 90,000. Ukraine is a leader in Europe in the growth of new cases of COVID-19 and mortality from this disease. The search for effective treatment regimens and new approaches to the management of patients with coronavirus disease in order to reduce the severity of coronavirus disease, reduce mortality, the number of complications and improve the rehabilitation period is very important nowadays. The aim of the work. To determine the main causes of mortality in patients with severe COVID-19 by analyzing the frequency and structure of complications in deceased patients. Materials and methods. The study conducted a retrospective analysis of 122 medical charts of deceased patients with COVID-19 who were hospitalized in a communal non-profit enterprise “Kyiv city clinical hospital №17” for the period from September 2020 to November 2021. Results and discussion. The overall mortality among patients with COVID-19 was 9.3%, in the intensive care unit (ICU) – 48.4%. The most common causes of death in patients with COVID-19 were: respiratory failure (RF) – 100% of cases, pulmonary embolism (PE) and acute heart failure (AHF) - about 60%. The average length of stay of patients in inpatient treatment was 11.67 ± 8.05 days, and in the intensive care unit – 7.94 ± 6.24 days. The mean age of patients hospitalized in the ICU was 63.5 ± 12.9 years and the mean age of patients who died was 71.2 ± 10.29 years. Prognostically significant criteria for lethal consequences were the presence of comorbidity: cardiovascular diseases- 92.3%, endocrine system diseases – 28.4%, nervous system diseases – 23.07%, kidney diseases – 9.6%, cancer – 9,6%, autoimmune conditions – 7.69%, varicose veins – 5.7%, respiratory system diseases – 5.7%. In patients with fatal outcome lymphopenia (84.6%) was observed in patients on admission to the ICU. Vasopressor and inotropic support was performed in 50 % of patients with COVID-19. In 25 % of those who died during long-term treatment and long-term respiratory support, there was the development of multiple organ failure, which in most cases was the point of no return. Conclusions. The most common causes of death were: respiratory failure, thrombosis, acute cardiovascular failure, sepsis and multiple organ failure. The main nature of the complications is common, but the cohort may be affected by different factors and the percentage of complications may differ in other hospitals.
在乌克兰,疫情期间登记的COVID-19病例超过350万例,死亡人数接近9万人。在新发COVID-19病例和死亡率增长方面,乌克兰在欧洲处于领先地位。寻找有效的治疗方案和治疗新方法,以降低冠状病毒病的严重程度,降低死亡率,减少并发症的发生,延长康复期,是当前研究的重要内容。工作的目的。通过分析死亡患者并发症的发生频率和结构,确定重症COVID-19患者死亡的主要原因。材料和方法。该研究对2020年9月至2021年11月期间在社区非营利企业“基辅市第17临床医院”住院的122例COVID-19死亡患者的病历进行了回顾性分析。结果和讨论。COVID-19患者的总死亡率为9.3%,重症监护病房(ICU)的总死亡率为48.4%。COVID-19患者最常见的死亡原因是:呼吸衰竭(RF) - 100%的病例,肺栓塞(PE)和急性心力衰竭(AHF) -约60%。住院患者平均住院时间为11.67±8.05 d,重症监护病房平均住院时间为- 7.94±6.24 d。ICU住院患者平均年龄为63.5±12.9岁,死亡患者平均年龄为71.2±10.29岁。致命后果的预后显著标准是存在合并症:心血管疾病- 92.3%,内分泌系统疾病- 28.4%,神经系统疾病- 23.07%,肾脏疾病- 9.6%,癌症- 9.6%,自身免疫性疾病- 7.69%,静脉曲张- 5.7%,呼吸系统疾病- 5.7%。在重症监护室(ICU)入院患者中,出现了致死性淋巴细胞减少(84.6%)。50%的COVID-19患者接受了血管加压剂和肌力支持。在长期治疗和长期呼吸支持期间死亡的患者中,有25%的患者出现了多器官功能衰竭,这在大多数情况下是无法挽回的。最常见的死亡原因是:呼吸衰竭、血栓形成、急性心血管衰竭、败血症和多器官衰竭。并发症的主要性质是共同的,但队列可能受到不同因素的影响,并发症的百分比可能在其他医院有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.40
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0.00%
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56
审稿时长
4 weeks
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