Derivation of maternal dietary patterns accounting for regional heterogeneity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-10-18 DOI:10.1111/rssc.12604

Briana J. K. Stephenson, Amy H. Herring, Andrew F. Olshan

引用次数: 3

Abstract

Latent class models are often used to characterise dietary patterns. Yet, when subtle variations exist across different sub-populations, overall population patterns can be masked and affect statistical inference on health outcomes. We address this concern with a flexible supervised clustering approach, introduced as Supervised Robust Profile Clustering, that identifies outcome-dependent population-based patterns, while partitioning out subpopulation pattern differences. Using dietary data from the 1997–2011 National Birth Defects Prevention Study, we determine how maternal dietary profiles associate with orofacial clefts among offspring. Results indicate mothers who consume a higher proportion of fruits and vegetables compared to land meats lower the proportion of progeny with orofacial cleft defect.

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解释区域异质性的母体饮食模式的推导

潜在类别模型通常用于描述饮食模式。然而，当不同亚群之间存在细微差异时，总体人口模式可能被掩盖，并影响对健康结果的统计推断。我们通过一种灵活的监督聚类方法来解决这个问题，该方法被称为监督鲁棒概要聚类，它可以识别结果依赖的基于种群的模式，同时划分出亚种群模式差异。利用1997-2011年国家出生缺陷预防研究的饮食数据，我们确定了母亲的饮食特征与后代的口面部裂之间的关系。结果表明，与陆地肉类相比，食用水果和蔬菜比例较高的母亲，其后代患口腔面部缺陷的比例较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.