Narrowband Ultraviolet B (NB-UVB) Phototherapy in Psoriasis: A Retrospective Study

Faida Ufaira Prameswari, C. Prakoeswa, Widiana Ferriastuti
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Abstract

Background: Psoriasis with higher Psoriasis Area and Severity Index (PASI) scores correlate with impaired quality of life. Assessing narrowband ultraviolet B (NB-UVB) phototherapy as a new therapy option in Indonesia is necessary to find the most effective treatment for psoriasis patients. Purpose: To determine the usage of NB-UVB phototherapy and the therapy response in psoriasis patients. Methods: This retrospective descriptive observational study was conducted at Dr. Soetomo General Academic Hospital Surabaya in March 2019-November 2020. The variables were collected through medical records. Result: A total of 28 patients were obtained at this study. Psoriasis type plaque/vulgaris were found in 92.9% of the patients. The patients mostly started with PASI score >10 with the initial dose of NB-UVB phototherapy is 260 mJ/cm2. The most common initial phototherapy frequency is 3 times per week (53.6%). The latest dose and frequency distribution was varied in each subject. The mean total number of sessions was 31.54 ± 20.549. Patients were also administered various combination therapy. The majority of patients had missed NB-UVB phototherapy sessions and the phototherapy dose needed to be reduced (57.1%). The achievement of PASI-75 (treatment success) was mostly achieved by subjects that went through 40-60 sessions of phototherapy and subjects with psoriasis type plaque/vulgaris. Conclusion: The achievement of PASI-75 was found to be low (17.5%), influenced by multiple factors such as the total number of NB-UVB phototherapy sessions, combination therapy, dose of NB-UVB phototherapy, frequency of NB-UVB phototherapy, and the level of patient compliance to therapy.
窄带紫外线B (NB-UVB)光疗治疗银屑病的回顾性研究
背景:银屑病的银屑病面积和严重程度指数(PASI)评分较高与生活质量受损相关。评估窄带紫外线B (NB-UVB)光疗在印度尼西亚作为一种新的治疗选择是必要的,以找到银屑病患者最有效的治疗方法。目的:探讨NB-UVB光疗在银屑病患者中的应用及疗效。方法:这项回顾性描述性观察性研究于2019年3月至2020年11月在泗水Soetomo综合学术医院进行。这些变量是通过医疗记录收集的。结果:本研究共获得28例患者。92.9%的患者存在银屑病型斑块/寻常型。大多数患者开始时PASI评分>10,NB-UVB光疗的初始剂量为260 mJ/cm2。最常见的初始光疗频率为每周3次(53.6%)。每个受试者的最新剂量和频率分布是不同的。平均总次数为31.54±20.549次。患者还接受了各种联合治疗。大多数患者错过了NB-UVB光疗疗程,需要减少光疗剂量(57.1%)。达到PASI-75(治疗成功)的主要是经过40-60次光疗的受试者和银屑病型斑块/寻常型受试者。结论:受NB-UVB光疗总次数、联合治疗、NB-UVB光疗剂量、NB-UVB光疗频率、患者对治疗依从性等因素的影响,PASI-75治疗成功率较低(17.5%)。
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