Effect of Vitamins C and E On Nonylphenol–Induced Dna Damage and Tefu Gene Expression in Drosophila Melanogaster

IF 0.5 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES

Biology and Environment-Proceedings of the Royal Irish Academy Pub Date : 2022-09-01 DOI:10.1353/bae.2022.0005

Fahriye Zemheri-Navruz, N. Bulut, Y. Şenses, C. Uğuz

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引用次数: 1

Abstract

ABSTRACT:Nonylphenol (NP) is one of the major environmental endocrine disrupters that can cause oxidative damage. Vitamin C (ascorbic acid) and vitamin E (α-tocopherol) are powerful antioxidants that could offset the effects of NP and are compounds that should be taken daily. In this study, the potential effects of the separate and combined administration of NP (1 and 10 mg/L) and vitamins C and E (25 mg/L) on DNA damage and telomere fusion (TEFU) gene expression in Drosophila melanogaster, a model organism, were investigated over 40 days. For the NP-administered groups, DNA damage increased while vitamins C and E reduced these effects, especially those induced by a co-administered group of NP and vitamin E. Furthermore, telomerase and DNA damage-associated TEFU gene expression levels increased in the NP-administered groups compared to the control group, while they decreased in the vitamin C and E administered groups. Consequently, it was concluded that vitamin C and E prevents the negative effects of NP on DNA damage.

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维生素C和E对壬基酚诱导的黑胃果蝇Dna损伤和Tefu基因表达的影响

摘要:壬基酚(NP)是一种主要的环境内分泌干扰物，可引起氧化损伤。维生素C(抗坏血酸)和维生素E (α-生育酚)是强大的抗氧化剂，可以抵消NP的影响，是应该每天服用的化合物。在本研究中，研究了NP(1和10 mg/L)和维生素C和E (25 mg/L)分别和联合给药对模式生物黑腹果蝇DNA损伤和端粒融合(TEFU)基因表达的潜在影响。对于NP组，DNA损伤增加，而维生素C和E减少了这些影响，特别是那些由NP和维生素E共同给药组诱导的。此外，与对照组相比，端粒酶和DNA损伤相关的TEFU基因表达水平在NP给药组中增加，而在维生素C和E给药组中减少。由此可见，维生素C和E可预防NP对DNA损伤的负面影响。

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来源期刊

Biology and Environment-Proceedings of the Royal Irish Academy 环境科学-环境科学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The journal aims to offer a broad coverage of the subject area, including the following: - biology and ecology of the Irish flora and fauna - microbial ecology - animal, plant and environmental physiology - global change - palaeoecology and palaeoclimatology - population biology; conservation of genetic resources - pollution and environmental quality; ecotoxicology - environmental management - hydrology - land use, agriculture, soils and environment. Submissions on other relevant topics are also welcome, and papers of a cross-disciplinary nature are particularly encouraged.