Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial

FuZhou Wang , XiaoFeng Shen , XiRong Guo , ShiQin Xu , LiangLiang He , YuSheng Liu
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引用次数: 2

Abstract

Background

Pain after uterine curettage has not been clearly evaluated. This study was designed to investigate the hypothesis that flurbiprofen axetil used prior to curettage on abortion could decrease 50% pain from uterine contraction.

Methods

Ninety seven ASA physical status I–II patients, undergoing elective uterine apoxesis, were allocated to this randomized double-blind controlled study and assigned into one of two groups (n = 45). In the flurbiprofen group, patients received an i.v. injection of flurbiprofen 50 mg in 5 ml 10 min prior to propofol anesthesia. The control group received the same volume of saline injection. Morphine 0.04 mg/kg was used as the rescue drug for uncontrolled pain. Visual analog scale for analgesia at rest, satisfaction with analgesia, morphine consumption and side effects were recorded.

Results

A total of 87 patients completed the study. The intention-to-treat number of patients was 45 in each group. Flurbiprofen group evidenced effective analgesia (vs. saline P = 0.019), with better satisfaction (P = 0.015), lower incidence of nausea, dizziness and drowsiness, pruritus, dry mouth and uterine bleeding than the saline control. The flurbiprofen group consumed less morphine in 1 h 0.6 mg (interquartile 0.1–1.2), vs. saline group 3.7 mg (interquartile 1.5–4.6) (P = 0.049). The number of patients needed to treat was 2 in the flurbiprofen group.

Conclusion

Preoperative flurbiprofen axetil 50 mg is a clinically effective analgesic means after uterine curettage on abortion.

氟比洛芬酯在人工流产子宫刮除后的镇痛效果:一项随机对照试验
背景子宫刮除后的疼痛尚未得到明确的评估。本研究旨在探讨在人工流产刮宫术前使用氟比洛芬酯可以减少50%的子宫收缩疼痛的假设。方法将97例ASA I-II期择期子宫排空患者随机分为两组(n = 45),进行双盲对照研究。氟比洛芬组患者在异丙酚麻醉前10分钟静脉注射氟比洛芬50mg / 5ml。对照组给予等量生理盐水注射。吗啡0.04 mg/kg作为疼痛失控的抢救药物。记录静息镇痛、镇痛满意度、吗啡用量及不良反应的视觉模拟量表。结果共87例患者完成研究。每组意向治疗人数为45人。氟比洛芬组镇痛效果明显(与生理盐水组比较P = 0.019),患者满意度较高(P = 0.015),恶心、头晕困倦、瘙痒、口干、子宫出血发生率低于生理盐水组。氟比洛芬组1 h吗啡消耗量少,0.6 mg(0.1 ~ 1.2),生理盐水组3.7 mg(1.5 ~ 4.6),差异有统计学意义(P = 0.049)。氟比洛芬组需要治疗的患者为2例。结论术前应用氟比洛芬酯50mg是一种临床有效的人工流产刮宫后镇痛手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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