Features of Biogenesis of Vesicles of External Membranes of Microorganisms, theirImmunogenic, Protective and Adjuvant Ability

N. Omelchenko, I. A. Ivanova, O. V. Duvanova, E. S. Shipko, A. Filippenko, A. Trufanova
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Abstract

Relevance. The process of production of outer membrane vesicles by bacteria is the main mechanism in intercellular communication and an intermediary in relationships of a very different nature (symbiosis, commensalism and parasitism), therefore, the study of the role of vesicles in the pathogenesis and immunogenesis of bacteria is an important and timely task.Aims. The purpose of this research was the analysis of scientific publications Russian and foreign journals for the period from 2002 to 2021 from the bibliographic databases of eLibrary.Ru, PubMed®, MEDLINE, dedicated to vesicles of outer membranes formed in various types of pathogenic and non-pathogenic bacteria.Conclusion. The study of the structure, factors of formation, functional significance of the mechanisms of action of bacterial vesicles, as well as the role of these structures in the pathogenesis and immunogenesis of various diseases, including especially dangerous ones, makes it possible to create new preventive drugs based on them. The use of vesicles as means of delivery of biological drugs and various antigens opens up new opportunities for improving the therapy and prevention of infections.
微生物外膜囊泡的生物发生特征及其免疫原性、保护性和佐剂性
的相关性。细菌外膜囊泡的产生过程是细胞间通讯的主要机制,是不同性质关系(共生、共生和寄生)的中介,因此,研究囊泡在细菌的发病机制和免疫发生中的作用是一项重要而及时的任务。本研究的目的是分析2002年至2021年期间来自图书馆书目数据库的俄罗斯和外国期刊的科学出版物。Ru, PubMed®,MEDLINE,致力于各种致病性和非致病性细菌形成的外膜囊泡。研究细菌囊泡的结构、形成因素、作用机制的功能意义,以及这些结构在各种疾病(包括特别危险的疾病)的发病和免疫发生中的作用,使基于它们开发新的预防药物成为可能。利用囊泡作为生物药物和各种抗原的递送手段,为改善感染的治疗和预防开辟了新的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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