Microwave Assisted, Silica Gel Mediated, Solvent Free, Michael-Addition of Aryl Methyl Ketones with Chalcones for the Synthesis of 1,3,5-triarylpentane-1,5-diones

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-06-30 DOI:10.29356/jmcs.v66i3.1706

Chithiravel Rengasamy, Rajaguru Kandasamy, Muthusubramanian Shanmugam

引用次数: 0

Abstract

Abstract. A series of symmetrical/unsymmetrical 1,3,5-Triarylpentane-1,5-diketone derivatives have been prudently synthesized via direct Michael addition of Chalocones with Aryl Methyl Ketones using microwave irradiation using Silica gel without any solvents. This method affords several advantages such as operational simplicity, short reaction time and easy work up by recrystallization and excellent yields. Resumen. Se prepararó una serie de derivados simétricos y asimétricos de 1,3,5-triaril-1,5-pentanodiona, a través de la adición de Michael entre arilmetilcetonas y chalconas empelando microondas y gel de sílice con y sin disolvente. El método ofrece ventajas como simplicidad operativa, reducción de los tiempos de reacción y fácil procesamiento por recristaización, así como excelentes rendimientos.

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微波辅助，硅胶介导，无溶剂，芳基甲基酮与查尔酮的michael加成合成1,3,5-三芳基戊烷-1,5-二酮

Abstract。而A series of symmetrical / unsymmetrical 1,3,5-Triarylpentane-1,5-diketone derivatives prudently synthesized通过direct迈克尔addition of Chalocones with Aryl Methyl Ketones using静止irradiation using Silica凝胶without any溶剂。这种方法有几个优点，如操作简单、反应时间短、易于再结晶和优异的产量。摘要。通过在芳基甲基酮和查尔酮之间加入Michael，用微波和硅胶填充溶剂和不溶剂，制备了一系列对称和不对称的1,3,5-三芳基-1,5-戊二酮衍生物。该方法具有操作简单、反应时间短、重结晶加工方便、收率高等优点。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.