Musa paradisiaca Linn Mucilage as a Disintegrant in Design of Fast Dissolving Tablets

Abstract

Objectives: The aim of the present work was to prepare and evaluate fast dissolving tablets of metoclopramide hydrochloride with a view to enhance patient compliance and minimizes the side effects. Methodology: In this study, fast dissolving tablets of metoclopramide were formulated by direct compression method using mucilages of Musa paradisiaca Linn (banana fruit), Cucurbita pepo var. turbinata (cucurbita maxima pulp), Ceratonia siliqua Linn (locust bean seeds) as natural disintegrants and crospovidone as a synthetic superdisintegrant in different ratios with directly compressible mannitol (Pearlitol SD 200) as a diluent to enhance the mouth feel. The prepared formulations were evaluated for hardness, friability, drug content, in vitro dispersion time, wetting time, water absorption ratio, in vitro drug release studies, stability studies and excipients interaction studies. Results: Among all the formulations, the formulation (FBP3) containing 8%w/w mucilage of Musa paradisiaca Linn was the overall best formulation (t 50% 2 min) based on in vitro drug release studies. Stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05). Conclusion: From the above studies, it can be concluded that fast dissolving tablets of metoclopramide can be prepared using different mucilages as a natural disintegrant for faster dispersion and disintegration in the mouth.