Adverse effect of Nitroxynil and Albendazole on rabbits

Abstract

Correspondence to: Eman Mohammed; Tel: +201099443698; Email: alfy79@gmail.com emanel Objective: The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1, 7 and 14 days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results: The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.