Plasma level of calcitonin gene-related peptide in the diagnosis of episodic migraine with comorbid conditions

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
O. Dubenko, A. O. Chernenko
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Abstract

Comorbid and co-occurring diseases are risk factors for the progression of episodic migraine to chronic migraine. Biomarkers for migraine could help with diagnosis and treatment selection and monitoring. Aim. To examine the role of the plasma level of calcitonin-gene-related peptide (CGRP) in the diagnosis of episodic migraine in combination with comorbid conditions in the form of cervicalgia and psychoemotional disorders. Materials and methods. The study included 112 patients (84 women, 28 men; mean age 18-58 years), episodic migraine with typical aura – 17, without aura – 60. Patients were divided into 3 groups: I – episodic migraine with cervicalgia (n = 42), II – episodic migraine only (n = 35), III – cervicalgia only (n = 35). The Visual Analogue Scale, Migraine Disability Assessment (MIDAS) score, Headache Impact Test (HIT-6), Neck Disability Index, State-Trait Anxiety Inventory, Beck’s Depression Inventory and the number of days with headache were assessed. The control group consisted of 30 healthy persons to compare the level of CGRP. The serum level of CGRP was determine by enzyme-linked immunosorbent assay using the sandwich ELISA principle. Results. Plasma level of CGRP was higher in groups I and II compared with group III (P = 0.012543), where it did not differ from the control (51.48 ± 5.08 pg/ml). The highest level of CGRP was observed in group I (242.98 ± 5.08 pg/ml) in comparison with group II (145.82 ± 15.38 pg/ml, P = 0.000341). Co-occurring neck-pain in patients with episodic migraine was associated with mood and anxiety disorders. Migraine severity, according to the MIDAS score, was most significantly influenced by plasma level of CGRP, severity of subjective and objective symptoms of headache by the HIT-6, level of State-anxiety and Trait-anxiety, number of days with headache during the last 3 months. Conclusions. The serum level of CGRP is a reliable diagnostic and differential diagnostic laboratory biomarker for episodic migraine. Additional painful syndrome such as cervicalgia influences CGRP level and daily activity, mood and anxiety disorders in episodic migraine patients.
血浆降钙素基因相关肽水平对伴有合并症的发作性偏头痛的诊断价值
合并症和并发疾病是发作性偏头痛发展为慢性偏头痛的危险因素。偏头痛的生物标志物有助于诊断、治疗选择和监测。探讨血浆降钙素基因相关肽(CGRP)水平在诊断伴有颈痛和精神情绪障碍的发作性偏头痛中的作用。材料和方法。该研究包括112例患者(84例女性,28例男性;平均年龄18-58岁),有典型先兆的发作性偏头痛- 17岁,无先兆- 60岁。患者分为3组:1 -发作性偏头痛伴颈痛(n = 42), II -仅发作性偏头痛(n = 35), III -仅颈痛(n = 35)。评定视觉模拟量表、偏头痛失能评定(MIDAS)评分、头痛影响测验(HIT-6)、颈部失能指数、状态-特质焦虑量表、贝克抑郁量表和头痛天数。对照组为30名健康人,比较CGRP水平。采用夹心ELISA法,采用酶联免疫吸附法测定血清CGRP水平。ⅰ组和ⅱ组血浆CGRP水平高于ⅲ组(P = 0.012543),与对照组(51.48±5.08 pg/ml)无显著差异。CGRP水平I组(242.98±5.08 pg/ml)高于II组(145.82±15.38 pg/ml, P = 0.000341)。发作性偏头痛患者同时发生的颈部疼痛与情绪和焦虑障碍有关。根据MIDAS评分,血浆CGRP水平、HIT-6主观和客观头痛症状的严重程度、状态焦虑和特质焦虑水平、最近3个月内头痛天数对偏头痛严重程度的影响最为显著。血清CGRP水平是发作性偏头痛可靠的诊断和鉴别诊断实验室生物标志物。额外的疼痛综合征,如颈痛会影响发作性偏头痛患者的CGRP水平和日常活动、情绪和焦虑障碍。
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
72
审稿时长
8 weeks
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