Article of Significant Interest Selected from This Issue by the Editors

{"title":"Article of Significant Interest Selected from This Issue by the Editors","authors":"","doi":"10.1128/ec.00034-15","DOIUrl":null,"url":null,"abstract":"Gjini et al. (p. 789 – 804) investigated how targeted disruption of the gene encoding Tet2, a DNA methylcytosine oxidase crucial for converting 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), affects zebrafish hematopoiesis. Zebrafish homozygous for tet2 inactivation exhibited low levels of 5-hmC specifically in hematopoietic cells and developed myelodysplasia of the kidney marrow at 11 months of age. Over the next 10 months, this disorder evolved to anemia and myelodysplastic syndrome. The zebrafish model of tet2 loss described is ideal for small-molecule screens in embryos to identify compounds with specific activity against tet2 mutant hematopoietic stem cells.","PeriodicalId":11891,"journal":{"name":"Eukaryotic Cell","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eukaryotic Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/ec.00034-15","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Gjini et al. (p. 789 – 804) investigated how targeted disruption of the gene encoding Tet2, a DNA methylcytosine oxidase crucial for converting 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), affects zebrafish hematopoiesis. Zebrafish homozygous for tet2 inactivation exhibited low levels of 5-hmC specifically in hematopoietic cells and developed myelodysplasia of the kidney marrow at 11 months of age. Over the next 10 months, this disorder evolved to anemia and myelodysplastic syndrome. The zebrafish model of tet2 loss described is ideal for small-molecule screens in embryos to identify compounds with specific activity against tet2 mutant hematopoietic stem cells.
由编辑从本期杂志中选出的具有重要意义的文章
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Eukaryotic Cell
Eukaryotic Cell 生物-微生物学
自引率
0.00%
发文量
0
审稿时长
1 months
期刊介绍: Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信