MODIFIKASI AMILUM GANYONG (CANNA DISCOLOR LINDL) SECARA ENZIMATIS DENGAN BAKTERI LACTOBACILUS ACIDOPHILUS SEBAGAI EKSIPIEN TABLET

Deny Puriyani Azhary
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Abstract

Canna starch is one type of starch that has potentially to be used as tablet excipient. Natural canna starch has poor flow properties and compressibility. Therefore, canna starch is modified by enzymatically with Lactobacillus acidophilus (lactic acid bacteria) that can produce α-amylase enzyme. The α-amylase enzyme capable of decomposing and altering microscopic structure of starch then can improve the flow properties and starch compressibility. The aim of this research to know the influence of enzymatically modified with Lactobacillus acidophilus bacteria on physical properties of canna starch. Enzymatically modified was conducted by using Lactobacillus acidophilus 3% (b/v) for 72 hours. The results showed that enzymatically modified using Lactobacillus acidophilus bacteria significantly influence the physical properties of canna starch, change the particle size of starch, improve the flow properties and compressibility and can be used as tablet excipient
肌甘蔗酸片(CANNA DISCOLOR)的酶与菌属acitophilus培养为正片
美人蕉淀粉是一种有潜力用作片剂辅料的淀粉。天然美人蕉淀粉具有较差的流动性和压缩性。因此,利用能产生α-淀粉酶的嗜酸乳杆菌(乳酸菌)对美人蕉淀粉进行酶促改性。α-淀粉酶能够分解并改变淀粉的微观结构,从而改善淀粉的流动性能和可压缩性。本研究的目的是了解嗜酸乳杆菌对美人蕉淀粉进行酶修饰对其物理性质的影响。用3%嗜酸乳杆菌(b/v)酶修饰72小时。结果表明,嗜酸乳杆菌对美人蕉淀粉进行酶促改性后,其物理性质显著改变,淀粉粒度改变,流动性和可压缩性改善,可作为片剂辅料
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