Fabrication of Magnetic Nanocomposites Using Natural Polymer Coating to Grain and Ciprofloxacin

Abstract

In this study, we try to stabilize magnetic nanoparticles (Fe3O4) with natural granular polymer (granular mucilage as a natural, biocompatible and biodegradable coating) and then load the drug ciprofloxacin on these nanoparticles. Then, structural, magnetic, physicochemical, colloidal and antibacterial properties of the samples using various characterization tools and tests such as X-ray diffraction (XRD) analysis, transmission electron microscopy (TEM) analysis, FEE-SEM field scanning electron microscopy (SEM) Vibrating Sample Magnetometry (VSM), Infrared Fourier Analysis (FTIR), Optical Spectroscopy (UV-Vis), Dynamic Light Scattering (DLS), Nanoparticle Specific Surface (BET) and Testing The antibacterial property of disk diffusion must be investigated [21]. XRD results as well as structural analysis of the samples confirm the magnetite phase with high purity. The results of FE-SEM and TEM analyzes indicate spherical morphology and very small size of magnetite nanoparticles (average 13 nm). The results of DLS analysis show a hydrodynamic diameter of 81.9 to 119.2 nm for magnetic nanoparticles with different structures. Zeta potential values ​​for magnetic nanoparticles are between -0.28 and -55.2 mV, indicating suitable colloidal stability of the nanoparticles for biological applications. The VSM results indicate the high saturation magnetization of the samples as well as the small amounts of the forcing field and the residual magnetization of the samples, which indicates the superpromagnetic property of the nanoparticles.