Evaluation of Sorghum bicolor (L.) Moench on the Reduction of Creatinine Levels and Its Antioxidant Properties In vitro

Dhaka University Journal of Pharmaceutical Sciences Pub Date : 2022-12-28 DOI:10.3329/dujps.v21i2.63117

Ogochukwu Immaculate Obika, A. Oyawaluja, J. Oiseoghaede, O. Odukoya, Ngozi Afulenu Obika Ndiri

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Abstract

The study investigated the effect of Sorghum bicolor (L.) Moench extract on the renal activity of both normal and ailing patients. Phytochemical analysis, antioxidant activity, vacuum liquid chromatography and TLC were carried out. The creatinine reduction ability was analyzed using Jaffe’s method for clean-catch spot urine samples of normal, diabetic and hypertensive patients. S. bicolor showed strong antioxidant activity with an IC50 value of 52.17 μg/ml, compared to the standard vitamin C with an IC50 value of 40.59 μg/ml. Statistical analysis (ANOVA) result showed a significant difference between the patients’ urine (rows) (p-value = 2.77×10–08) and a significant difference between the dose treatments (columns) (p-value = 8.38×10–14). Whilst different fractions of S. bicolor at different concentrations showed varying effects on the creatinine concentration, it reduced creatinine level in low doses and has antioxidant properties. Dhaka Univ. J. Pharm. Sci. 21(2): 165-172, 2022 (December)

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高粱双色的评价体外降低肌酐水平及其抗氧化性能的研究

研究了高粱双色剂(L.)芒草提取物对正常和疾病患者肾脏活动的影响。进行了植物化学分析、抗氧化活性分析、真空液相色谱和薄层色谱分析。采用Jaffe法对正常人、糖尿病患者和高血压患者的净斑尿样进行肌酐还原能力分析。与标准维生素C的IC50值40.59 μg/ml相比，双色参具有较强的抗氧化活性，IC50值为52.17 μg/ml。统计分析(ANOVA)结果显示，患者尿液(行)之间存在显著差异(p值= 2.77×10-08)，剂量治疗(列)之间存在显著差异(p值= 8.38×10-14)。不同部位不同浓度的双色参对肌酐浓度的影响不同，但在低剂量下可降低肌酐水平，并具有抗氧化作用。达卡大学药学院。科学21(2):165- 172,2022(12月)

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Dhaka University Journal of Pharmaceutical Sciences

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