Ovarian cancer: Ca2+-dependent and Ca2+-independent isoforms of NO-synthase functioning in blood lymphocytes of women

Abstract

The purpose of the work was to study the activity and kinetic parameters of isoforms of NO-synthase blood lymphocytes in women with ovarian cancer. Ovarian cancer is considered to be one of the most severe diseases of the female reproductive tract. The study of the pathogenesis of ovarian cancer is being directed to improve methods of diagnosis and detection of tumor formation process at an early stages. It is known that metabolism of L -arginine and synthesis of nitric oxide (NO) plays an important role in carcinogenesis and tumor growth. It is assumed that NO modulates can-cer-dependent events, including angiogenesis, apoptosis, cell cycle, invasion imaginary affinity constant inducible isoform of NO-synthase to arginine was in 5.4 times lower than that of constitutive isoforms of NO-synthase of blood lymphocytes of the control group and inhibition of constitutive isoform occurs by competitive type –by reducing the rate of enzyme turnover.