The Effect of Grapex on Wounds Healing in Patients with Scleroderma: A Randomized Controlled Clinical Trial

Medical laboratory sciences Pub Date : 2021-03-13 DOI:10.22037/AMLS.V7.31059

A. Hemmati, Z. Zayeri, Elham Rajaei, M. Ghanavati

{"title":"The Effect of Grapex on Wounds Healing in Patients with Scleroderma: A Randomized Controlled Clinical Trial","authors":"A. Hemmati, Z. Zayeri, Elham Rajaei, M. Ghanavati","doi":"10.22037/AMLS.V7.31059","DOIUrl":null,"url":null,"abstract":"Background and Aim: Scleroderma (SC) is a connective tissue disease, characterized by diffuse microangiopathy and excessive production of collagen. The current study aimed to investigate the effectiveness of Grapex extract in improving the wound of patients with scleroderma. \nMethods: This randomized controlled double-blind clinical trial was performed from 2018 to 2019 on patients with scleroderma referred to Golestan Hospital in Ahvaz, Iran. Forty patients with active SC were selected and randomly divided into two groups. Patients applied the ointment twice a day for 4 weeks on the surface of their wounds. After four weeks of using the cream, the rate of wound healing was determined by clinical examination of the wounds. \nResults: 6 people were excluded from the study due to the lack of referral and final analyzes were performed on 34 patients (16 patients in the control group and 18 patients in the case group). The results of this study showed that there was a significant difference between the two groups in terms of response to treatment (p <0.0001). At the end of the fourth week, 88.89% of the patients in the case group (16 of the 18 patients) achieved complete healing of the wounds in comparison with 18.75% of the control group (3 of the 16 patients). Neither the control group nor the case group had a significant association between response to treatment with age and gender of patients, type of scleroderma, duration of illness, and symptoms. \nConclusion: This study showed the effectiveness of Grapex cream ointment in healing scleroderma wounds. Therefore, Grapex cream is an effective, inexpensive, safe, and available medicine that can be used to accelerate wound healing in patients with scleroderma. \n*Corresponding Authors: Elham Rajaei, Email: elhamrj@gmail.com \nPlease cite this article as: Hemmati AA, Deris Zayeri Z, Rajaei E, Ghanavati M. The Effect of Grapex on Wounds Healing in Patients with Scleroderma: A Randomized Controlled Clinical Trial. Arch Med Lab Sci. 2021;7:1-10 (e1). https://doi.org/10.22037/amls.v7.31059","PeriodicalId":18401,"journal":{"name":"Medical laboratory sciences","volume":"167 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical laboratory sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22037/AMLS.V7.31059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Aim: Scleroderma (SC) is a connective tissue disease, characterized by diffuse microangiopathy and excessive production of collagen. The current study aimed to investigate the effectiveness of Grapex extract in improving the wound of patients with scleroderma. Methods: This randomized controlled double-blind clinical trial was performed from 2018 to 2019 on patients with scleroderma referred to Golestan Hospital in Ahvaz, Iran. Forty patients with active SC were selected and randomly divided into two groups. Patients applied the ointment twice a day for 4 weeks on the surface of their wounds. After four weeks of using the cream, the rate of wound healing was determined by clinical examination of the wounds. Results: 6 people were excluded from the study due to the lack of referral and final analyzes were performed on 34 patients (16 patients in the control group and 18 patients in the case group). The results of this study showed that there was a significant difference between the two groups in terms of response to treatment (p <0.0001). At the end of the fourth week, 88.89% of the patients in the case group (16 of the 18 patients) achieved complete healing of the wounds in comparison with 18.75% of the control group (3 of the 16 patients). Neither the control group nor the case group had a significant association between response to treatment with age and gender of patients, type of scleroderma, duration of illness, and symptoms. Conclusion: This study showed the effectiveness of Grapex cream ointment in healing scleroderma wounds. Therefore, Grapex cream is an effective, inexpensive, safe, and available medicine that can be used to accelerate wound healing in patients with scleroderma. *Corresponding Authors: Elham Rajaei, Email: elhamrj@gmail.com Please cite this article as: Hemmati AA, Deris Zayeri Z, Rajaei E, Ghanavati M. The Effect of Grapex on Wounds Healing in Patients with Scleroderma: A Randomized Controlled Clinical Trial. Arch Med Lab Sci. 2021;7:1-10 (e1). https://doi.org/10.22037/amls.v7.31059

查看原文本刊更多论文

葡萄素对硬皮病患者伤口愈合的影响:一项随机对照临床试验

背景与目的:硬皮病(SC)是一种结缔组织疾病，以弥漫性微血管病变和胶原蛋白过度产生为特征。本研究旨在探讨葡萄提取物对硬皮病患者创面的改善作用。方法:2018 - 2019年，对伊朗阿瓦士Golestan医院的硬皮病患者进行随机对照双盲临床试验。选择40例活动性SC患者，随机分为两组。病人将这种药膏涂抹在伤口表面，每天两次，持续4周。使用该药膏四周后，通过临床检查伤口的愈合速度来确定伤口的愈合速度。结果:6人因缺乏转诊而被排除在研究之外，34例患者(对照组16例，病例组18例)进行了最终分析。本研究结果显示，两组患者在治疗应答方面存在显著差异(p <0.0001)。第四周结束时，病例组有88.89%的患者(18例患者中有16例)伤口完全愈合，对照组有18.75%(16例患者中有3例)伤口完全愈合。对照组和病例组对治疗的反应与患者的年龄和性别、硬皮病类型、病程和症状之间均无显著关联。结论:本研究显示了葡萄膏膏对硬皮病创面的治疗效果。因此，Grapex面霜是一种有效、廉价、安全且可用的药物，可用于加速硬皮病患者的伤口愈合。*通讯作者:Elham Rajaei, Email: elhamrj@gmail.com本文署名:Hemmati AA, Deris Zayeri Z, Rajaei E, Ghanavati M.葡萄素对硬皮病患者伤口愈合的影响:一项随机对照临床试验。中华医学杂志，2011;7:1-10(1)。https://doi.org/10.22037/amls.v7.31059

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medical laboratory sciences

自引率

0.00%

发文量