J. Omura, K. Habbout, S. Martineau, S. Breuils-bonnet, V. Nadeau, F. Potus, Stephen L. Archer, R. Paulin, S. Provencher, O. Boucherat, S. Bonnet
{"title":"Long Non-coding RNA H19 in Right Ventricular Failure associated with Pulmonary Arterial Hypertension","authors":"J. Omura, K. Habbout, S. Martineau, S. Breuils-bonnet, V. Nadeau, F. Potus, Stephen L. Archer, R. Paulin, S. Provencher, O. Boucherat, S. Bonnet","doi":"10.1183/13993003.congress-2019.pa5040","DOIUrl":null,"url":null,"abstract":"Background: Right ventricular failure (RVF) is the major prognostic factor in pulmonary arterial hypertension (PAH). Recent Omics analyses have demonstrated the deregulation of several long non-coding RNAs (LncRNAs) in left heart failure, but their role in RVF remains unknown. The LncRNA H19 and its encoded miR-675 have been implicated in both cardiac hypertrophy and fibrosis (2 features of RVF) but never been studied in RVF. Methods and Results: By qRT-PCR, we showed in human RV biopsies obtained from control donors, compensated RV hypertrophy patients (CRVH, Cardiac index > 2.2) and decompensated RV hypertrophy patients (DRVH, PAH patients that died from RVF), that H19 and miR-675 were specifically up-regulated (p Conclusions: We demonstrated for the first time that H19 is implicated in the transition from CRVH to DRVH in human RVF. Circulating H19 represents a putative biomarker of RV function in PAH patients.","PeriodicalId":20724,"journal":{"name":"Pulmonary hypertension","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pulmonary hypertension","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1183/13993003.congress-2019.pa5040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Background: Right ventricular failure (RVF) is the major prognostic factor in pulmonary arterial hypertension (PAH). Recent Omics analyses have demonstrated the deregulation of several long non-coding RNAs (LncRNAs) in left heart failure, but their role in RVF remains unknown. The LncRNA H19 and its encoded miR-675 have been implicated in both cardiac hypertrophy and fibrosis (2 features of RVF) but never been studied in RVF. Methods and Results: By qRT-PCR, we showed in human RV biopsies obtained from control donors, compensated RV hypertrophy patients (CRVH, Cardiac index > 2.2) and decompensated RV hypertrophy patients (DRVH, PAH patients that died from RVF), that H19 and miR-675 were specifically up-regulated (p Conclusions: We demonstrated for the first time that H19 is implicated in the transition from CRVH to DRVH in human RVF. Circulating H19 represents a putative biomarker of RV function in PAH patients.
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