Development a quantitative method for the determination of misoprostol acid in human serum

Abstract

The present work aims to develop a qualitative quantitative method using the UPLC MS-MS equipment, for the determination of misoprostol ester through its metabolite, misoprostol acid, in human serum samples who consumed misoprostol ester for abortive purposes. This study was conducted in the Toxicology Laboratory of the Institute of Legal Medicine of the Public Ministry. At the national level there is no official method and internationally there are methods in similar teams1 The highly sensitive and specific qualiquantitative method of the UPLC MS-MS team, which is developed in the present study, can determine misoprostol ester through its serum acid misoprostol metabolite of pregnant women who have ingested misoprostol ester in abortive doses.