Treating mouse and rat tumors with direct current

Abstract

In vivo studies were conducted to evaluate the effectiveness of electrochemical treatment on animal tumor models. Radiation induced fibrosarcoma tumors were subcutaneously implanted on 157 female C3H/HeJ mice. When the tumor diameter reached 10 mm, 2 to 5 platinum electrodes were inserted into the tumor and treated with direct current. Larger fibrosarcomas were implanted on 34 female Fisher 344 rats, which were treated when the tumors reached 20-30 mm in length. In the second group of 24 rats, 12 rats were treated once, 10 twice and two thrice. Best mice cure rate, three months post treatment, calculated by the Kaplan-Meier method was 59.3% (n=27). For the 24 rats, 6 months post treatment, there were 18 living without tumors (75%). These results indicate that electrochemical treatment is effective on mouse and rat fibrosarcoma tumors.