Genetic Polymorphisms in Antioxidant Enzymes Modulate the Susceptibility of Idiosyncratic Antituberculous Drug‐Induced Liver Injury and Treatment Outcomes in Patients with Tuberculosis

Q. Sun, W. Sha, Haipeng Liu, Peng Wang, Zhi-bin Liu, Wen Sun, He-ping Xiao
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引用次数: 4

Abstract

The pathogenic mechanism of antituberculous drug‐induced liver injury (ATDILI) is associated with antioxidant enzymes. The objective of the present study was to investigate the associations of ATDILI susceptibility with genetic polymorphisms of antioxidant enzyme genes including nitric oxide synthase 2 (NOS2), thioredoxin reductase 1 (TXNRD1), superoxide dismutase 2 (SOD2), BTB domain and CNC homolog 1 (BACH1), and MAF bZIP transcription factor K (MAFK).
抗氧化酶的遗传多态性调节特异性抗结核药物诱导的结核病患者肝损伤的易感性和治疗结果
抗结核药物诱导肝损伤(ATDILI)的致病机制与抗氧化酶有关。本研究旨在探讨ATDILI易感性与一氧化氮合酶2 (NOS2)、硫氧还蛋白还原酶1 (TXNRD1)、超氧化物歧化酶2 (SOD2)、BTB结构域和CNC同源物1 (BACH1)、MAF bZIP转录因子K (MAFK)等抗氧化酶基因遗传多态性的关系。
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