GREEN ANALYTICAL METHOD FOR QUANTIFICATION OF SECNIDAZOLE IN TABLETS BY FOURIER-TRANSFORM INFRARED SPECTROSCOPY (FTIR)

Drug Analytical Research Pub Date : 2018-12-16 DOI:10.22456/2527-2616.88545

Jéssica Gonçalves Souza Lima, Bianca Aparecida de Marco, H. R. Salgado

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引用次数: 1

Abstract

Secnidazole is a medicine widely used in the treatment of bacterial and protozoal diseases. The free sale of this drug allows its easy access to the population and for this reason, the studies that involve the analysis of the quality control of this drug are extremely important to keep the results safe and reliable. Considering the great pharmacotherapeutic application of secnidazole and the great importance of developing new analytical methods that contribute to the environmen, the study was based on the development and validation of a new sustainable analytical method by Fourier-transform infrared spectroscopy (FT-IR) to identify and quantify secnidazole tablets. The method was duly validated according to the ICH guidelines, presenting precision, accuracy, selectivity, robustness and linearity in the concentration range of 0.5-1.3 mg/pellet. The application of this method in addition to being safe and reliable is highly favorable from an economic point of view since there is a significant reduction in the use of production costs as solvents and raw material, being fast and simple and can also be applied to other medicines.

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傅里叶变换红外光谱(ftir)定量塞克硝唑片剂的绿色分析方法

塞克硝唑是一种广泛用于治疗细菌和原生动物疾病的药物。这种药物的免费销售使得它很容易进入人群，因此，涉及分析这种药物的质量控制的研究对于保持结果的安全和可靠非常重要。考虑到塞克硝唑在药物治疗中的广泛应用，以及开发对环境有贡献的新分析方法的重要性，本研究基于傅里叶变换红外光谱(FT-IR)的可持续分析方法的开发和验证，以鉴定和定量塞克硝唑片。该方法在0.5 ~ 1.3 mg/粒的浓度范围内具有精密度、准确度、选择性、稳健性和线性。该方法的应用除了安全可靠外，从经济角度来看非常有利，因为它大大减少了作为溶剂和原料的生产成本，并且快速简单，也可以应用于其他药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug Analytical Research

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