ICPMS based multiplexed bioassay: Principles, approaches and progresses

IF 5.4 2区化学 Q1 INSTRUMENTS & INSTRUMENTATION

Applied Spectroscopy Reviews Pub Date : 2021-05-12 DOI:10.1080/05704928.2021.1918703

Ziyan Li, Rui Liu, Yi Lv

引用次数: 6

Abstract

Abstract Recent developments in multiplex bioassay around the theme of precision diagnostics have gained great focus. Inductively coupled plasma mass spectrometry (ICPMS) is emerging as a powerful platform for multiplex bioassay due to its high sensitivity, wide dynamic range, particularly its reliable multiplex sensing ability. This review discusses the progress being made in the multiplex bioassay applicating ICPMS, mainly emphasizes on varieties of biomarkers and methodological innovations. Also, we summarized limitations and proposed prospects to shed new light on the emergence of more powerful and application-oriented analytical methods.

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基于ICPMS的多重生物测定:原理、方法与进展

摘要近年来，围绕精确诊断主题的多重生物测定技术的发展受到了广泛关注。电感耦合等离子体质谱(ICPMS)以其高灵敏度、宽动态范围，特别是可靠的多路传感能力，正在成为多路生物测定的有力平台。本文综述了应用ICPMS进行多种生物检测的研究进展，重点介绍了生物标志物的多样性和方法的创新。此外，我们总结了局限性，并提出了展望，为更强大和面向应用的分析方法的出现提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Spectroscopy Reviews 工程技术-光谱学

CiteScore

13.80

自引率

1.60%

发文量

审稿时长

1 months

期刊介绍： Applied Spectroscopy Reviews provides the latest information on the principles, methods, and applications of all the diverse branches of spectroscopy, from X-ray, infrared, Raman, atomic absorption, and ESR to microwave, mass, NQR, NMR, and ICP. This international, single-source journal presents discussions that relate physical concepts to chemical applications for chemists, physicists, and other scientists using spectroscopic techniques.