Optimization of the process conditions for the extraction of rutin from Ruta graveolens L. by choline chloride based deep eutectic solvents

IF 0.6 4区工程技术 Q4 CHEMISTRY, MULTIDISCIPLINARY

Solvent Extraction Research and Development, Japan Pub Date : 2018-01-01 DOI:10.15261/SERDJ.25.109

M. Molnar, Martina Jakovljević, S. Jokić

引用次数: 15

Abstract

Extraction of rutin from Ruta graveolens L. leaves was performed in choline chloride based deep eutectic solvents (DESs). Firstly, rutin extraction was performed in five different DESs ; pure DESs and with different amounts of water added (25% and 50% v/v), for different times (1h, 3h and 6h) in order to find the best DES for further optimization. Choline chloride plus citric acid (1:1) was shown to be best DES and optimization of rutin extraction was performed using response surface methodology (RSM) based on the selected solvent and applying different extraction parameters: extraction time, temperature and water content. The rutin content was determined by HPLC and varied from 0.55 g/100 g of plant to 1.81 g/100 g of plant depending on the applied conditions. The best conditions for rutin extraction were found to be: a temperature of 70°C, an extraction time of 52 min and a water content of 27% for the extraction of 1.88g /100 g plant.

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以氯化胆碱为溶剂，对芦丁提取工艺条件进行了优化

采用氯化胆碱型深共晶溶剂(DESs)提取芦丁。首先，在5种不同的DESs中提取芦丁;在不同的时间(1h, 3h, 6h)，不同的水添加量(25%和50% v/v)，以找到最佳的DES进一步优化。以氯化胆碱与柠檬酸(1:1)为最佳萃取溶剂，采用响应面法(RSM)对芦丁的提取工艺进行了优化。采用高效液相色谱法测定芦丁含量，根据不同的应用条件，芦丁含量在0.55 g/100 g ~ 1.81 g/100 g之间变化。芦丁的最佳提取条件为:提取温度70℃，提取时间52 min，提取量为1.88g /100 g，提取率为27%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Solvent Extraction Research and Development, Japan 工程技术-工程：化工

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

1 months

期刊介绍： Solvent Extraction Research and Development, Japan (Solvent Extr. Res. Dev., Jpn.) is a periodical issued from Japan Association of Solvent Extraction (JASE) containing papers dealing with all aspects of solvent extraction and their related methods, underlying principles, and materials. Original articles, notes, technical reports, and critical reviews will be considered for publication. Original articles must be of reasonably broad scope and significance to the solvent extraction. Notes will originally describe novel work of a limited nature or especially significant work in progress. Authors can contribute some information of novel techniques, equipment or apparatus, reagents and diluents for solvent extraction as technical reports. Critical reviews will be received from the authors to whom the editorial committee asked to contribute.