Identifying Peptide Structures with THz Spectroscopy

J. Neu, Ayaka S. Hatano, E. Stone, Golo Storch, Jacob A. Spies, Scott J. Miller, C. Schmuttenmaer
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引用次数: 1

Abstract

Short peptides composed of only a few amino acid residues are of great interest due to their biological activity and have also been shown to exhibit catalytic activity. Identifying their dynamic $3\mathbf{D}$ structure is quintessential for studying structure - activity relations. We present temperature-dependent THz spectroscopy of tetrameric peptide catalysts. These THz spectra, supported by DFT calculations, allow us to distinguish structural features of different peptides.
太赫兹光谱法鉴定肽结构
由于其生物活性和催化活性,仅由少数氨基酸残基组成的短肽引起了人们的极大兴趣。识别它们的动态$3\mathbf{D}$结构是研究构效关系的关键。我们提出了四聚体肽催化剂的温度依赖太赫兹光谱。这些太赫兹光谱,由DFT计算支持,使我们能够区分不同肽的结构特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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