{"title":"Progressive use of nanocomposite hydrogels materials for regeneration of damaged cartilage and their tribological mechanical properties","authors":"P. Sagar, G. Kumar, A. Handa","doi":"10.1177/23977914231151487","DOIUrl":null,"url":null,"abstract":"Osteoarthritis (OA) is a non-inflammatory deteriorating debilitating state that bring about remarkable health and economic issues globally. Break down/deterioration of the articular cartilage (AC) is one of the pathologic characteristics of osteoarthritis (OA). Nanocomposite hydrogels (NCH) materials are evolving as a potential class of scaffolds for organ regeneration and tissue engineering. In recent years, innovative hydrogels specifically loaded with nanoparticles have been developed and synthesized with the goal of changing conventional cartilage treatments. The detailed development of a tailored nanocomposite hydrogels (NCH) material utilized for tissue engineering is presented in this review study. Also, the mechanical characteristics, particularly the tribological behavior, of these produced NCH have been highlighted. Large amounts of research and data on the hydrogel substance utilized in cartilage healing are summarized in the current review study. When determining future research gaps in the area of hydrogels for cartilage regeneration, such information will provide researchers an advantage to further develop NCH.","PeriodicalId":44789,"journal":{"name":"Proceedings of the Institution of Mechanical Engineers Part N-Journal of Nanomaterials Nanoengineering and Nanosystems","volume":"22 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Institution of Mechanical Engineers Part N-Journal of Nanomaterials Nanoengineering and Nanosystems","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/23977914231151487","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NANOSCIENCE & NANOTECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoarthritis (OA) is a non-inflammatory deteriorating debilitating state that bring about remarkable health and economic issues globally. Break down/deterioration of the articular cartilage (AC) is one of the pathologic characteristics of osteoarthritis (OA). Nanocomposite hydrogels (NCH) materials are evolving as a potential class of scaffolds for organ regeneration and tissue engineering. In recent years, innovative hydrogels specifically loaded with nanoparticles have been developed and synthesized with the goal of changing conventional cartilage treatments. The detailed development of a tailored nanocomposite hydrogels (NCH) material utilized for tissue engineering is presented in this review study. Also, the mechanical characteristics, particularly the tribological behavior, of these produced NCH have been highlighted. Large amounts of research and data on the hydrogel substance utilized in cartilage healing are summarized in the current review study. When determining future research gaps in the area of hydrogels for cartilage regeneration, such information will provide researchers an advantage to further develop NCH.
期刊介绍:
Proceedings of the Institution of Mechanical Engineers Part N-Journal of Nanomaterials Nanoengineering and Nanosystems is a peer-reviewed scientific journal published since 2004 by SAGE Publications on behalf of the Institution of Mechanical Engineers. The journal focuses on research in the field of nanoengineering, nanoscience and nanotechnology and aims to publish high quality academic papers in this field. In addition, the journal is indexed in several reputable academic databases and abstracting services, including Scopus, Compendex, and CSA's Advanced Polymers Abstracts, Composites Industry Abstracts, and Earthquake Engineering Abstracts.