Near-field single molecule spectroscopy

Abstract

Recent advances in near-field scanning optical microscopy (NSOM) make it possible to image single molecule emission with nanometric resolution and extend the single molecule spectroscopy work done at cryogenic temperature to the room temperature regime. With NSOM, molecular fluorescence can be spectrally and temporally resolved, allowing detailed studies of molecular interaction and dynamics on a single molecule basis with a spatial resolution beyond the diffraction limit.