Covalent Binding of C60 Fullerene to Quadricyclanes A Synthetic Avenue to Hexamethanofullerenes with Promising Antitumor Activity

Abstract

: The Bingel-Hirsch reaction was used to synthesize two new hexamethanofullerenes containing six quadricyclane fragments. Preliminary experiments have established that the synthesized compounds have a high antitumor effect in combination with cisplatin on human T-lymphoblastic leukemia cells (Jurkat cells). the activity of hexamethanofullerenes in on leukemia cells (Jurkat a significant (10-fold) increase in the number of dead cells in comparison with previously synthesized monomethanofullerenes containing one quadricyclane fragment.