Conformation-driven computing: simulating the context-conformation-action loop

Abstract

Function follows conformation in biological macromolecules. In general there are a number of possible conformational states. Which state is favored is determined by physicochemical context. The fusion of the features that comprise this context to form a particular conformational state is at the core of cellular control and biological information processing. We have developed a simulation system to investigate the information processing capabilities of networks of context-sensing macromolecules (to be illustrated by a simple example).