Endogenous phthalates as a prospective regulator of interspecific relations in a biocoenosis

L. Maksimova, T. N. Shafikova
{"title":"Endogenous phthalates as a prospective regulator of interspecific relations in a biocoenosis","authors":"L. Maksimova, T. N. Shafikova","doi":"10.21285/2227-2925-2022-12-3-424-437","DOIUrl":null,"url":null,"abstract":"It is widely believed that phthalates are xenobiotic pollutants whose prevalence in the environment is associated with their facilitated diffusion from plastic materials. Studies into the effect of synthetic phthalates on living organisms revealed their extremely negative action on the metabolism of animals and humans. The acting mechanism of these compounds is realised through a ligand-receptor pathway. Along with dioxins, polychlorinated biphenyls and similar compounds, phthalates are classified as endocrine disrupters. However, at present, sufficient evidence has been accumulated confirming the natural origin of phthalates. Thus, phthalates were de novo biosynthesised from labelled precursors in an algae culture. These compounds were detected in closed experimental systems, including cell cultures of highest plants, as well as those isolated from a number of bacterial, fungi, lowest and highest plant forms located far from the sources of technogenic pollution. The concept of phthalate biogenesis assumes the action of these compounds on living systems. Phthalates exhibit bactericidal and fungicidal action and compose allelopathic exudates, suppressing the growth of competing plant forms. Phthalates possess insecticidal and repellent properties. An analogy can be traced between the action of phthalates and endocrine disrupters of another chemical category, namely phytoestrogens, which regulate herbivorous mammal populations. A hypothesis is proposed about the biological role of endogenous plant phthalates representing secondary metabolic compounds. Exhibiting predominantly a shielding function, these compounds participate in the network of interactions between plants, animals, fungi and microorganisms. It should be noted that synthetic and endogenous phthalates are characterised by essential stereochemical differences, which can explain their different action on living organisms.","PeriodicalId":20601,"journal":{"name":"PROCEEDINGS OF UNIVERSITIES APPLIED CHEMISTRY AND BIOTECHNOLOGY","volume":"25 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PROCEEDINGS OF UNIVERSITIES APPLIED CHEMISTRY AND BIOTECHNOLOGY","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21285/2227-2925-2022-12-3-424-437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

It is widely believed that phthalates are xenobiotic pollutants whose prevalence in the environment is associated with their facilitated diffusion from plastic materials. Studies into the effect of synthetic phthalates on living organisms revealed their extremely negative action on the metabolism of animals and humans. The acting mechanism of these compounds is realised through a ligand-receptor pathway. Along with dioxins, polychlorinated biphenyls and similar compounds, phthalates are classified as endocrine disrupters. However, at present, sufficient evidence has been accumulated confirming the natural origin of phthalates. Thus, phthalates were de novo biosynthesised from labelled precursors in an algae culture. These compounds were detected in closed experimental systems, including cell cultures of highest plants, as well as those isolated from a number of bacterial, fungi, lowest and highest plant forms located far from the sources of technogenic pollution. The concept of phthalate biogenesis assumes the action of these compounds on living systems. Phthalates exhibit bactericidal and fungicidal action and compose allelopathic exudates, suppressing the growth of competing plant forms. Phthalates possess insecticidal and repellent properties. An analogy can be traced between the action of phthalates and endocrine disrupters of another chemical category, namely phytoestrogens, which regulate herbivorous mammal populations. A hypothesis is proposed about the biological role of endogenous plant phthalates representing secondary metabolic compounds. Exhibiting predominantly a shielding function, these compounds participate in the network of interactions between plants, animals, fungi and microorganisms. It should be noted that synthetic and endogenous phthalates are characterised by essential stereochemical differences, which can explain their different action on living organisms.
内源性邻苯二甲酸盐作为生物群落中种间关系的潜在调节剂
人们普遍认为邻苯二甲酸盐是一种外源性污染物,其在环境中的普遍存在与它们从塑料材料中容易扩散有关。对合成邻苯二甲酸酯对生物体的影响的研究表明,它们对动物和人类的新陈代谢具有极其负面的作用。这些化合物的作用机制是通过配体-受体途径实现的。邻苯二甲酸酯与二恶英、多氯联苯和类似化合物一起被列为内分泌干扰物。然而,目前已经积累了足够的证据来证实邻苯二甲酸盐的天然来源。因此,邻苯二甲酸盐是在藻类培养中从标记的前体重新生物合成的。这些化合物是在封闭的实验系统中检测到的,包括最高级植物的细胞培养,以及从远离技术污染源的一些细菌、真菌、最低级和最高级植物形式中分离出来的细胞培养。邻苯二甲酸酯生物发生的概念假定这些化合物在生命系统上的作用。邻苯二甲酸盐具有杀菌和杀真菌的作用,并形成化感分泌物,抑制竞争植物的生长。邻苯二甲酸酯具有杀虫和驱避的特性。邻苯二甲酸酯的作用与另一类化学物质的内分泌干扰物,即调节食草哺乳动物种群的植物雌激素,可以进行类比。提出了一种关于内源性植物邻苯二甲酸盐作为次生代谢化合物的生物学作用的假设。这些化合物主要表现为屏蔽功能,参与植物、动物、真菌和微生物之间的相互作用网络。应该指出的是,合成邻苯二甲酸酯和内源性邻苯二甲酸酯具有本质的立体化学差异,这可以解释它们对生物体的不同作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信