Macrophage scavenger receptor 1, a suppressor of HIV infection, is down-regulated in transgender females

Theresa L. Chang, Annie Wang, Alisa C Herbst, Cyril Hernandez, Jeet Vaishnav, A. Lemenze, S. Swaminathan, Michelle Dalla Piazza, D. Finkel, S. Bentsianov, N. Roche
{"title":"Macrophage scavenger receptor 1, a suppressor of HIV infection, is down-regulated in transgender females","authors":"Theresa L. Chang, Annie Wang, Alisa C Herbst, Cyril Hernandez, Jeet Vaishnav, A. Lemenze, S. Swaminathan, Michelle Dalla Piazza, D. Finkel, S. Bentsianov, N. Roche","doi":"10.4049/jimmunol.210.supp.75.44","DOIUrl":null,"url":null,"abstract":"\n Transgender people are at greater risk than cisgender people of acquiring HIV and other sexually transmitted infections. Globally, the risk of acquiring HIV infection is nearly 49 times higher in transgender women than in other populations. Although behavioral and psychosocial factors contribute to the higher HIV risk in transgender people, gender-affirming hormone (GAH) (i.e., testosterone for transgender individuals assigned female at birth or estrogen/antiandrogen for transgender individuals assigned male at birth) may alter immune cell functions, resulting in increased HIV transmission. We have profiled gene expression of PBMCs from transgender females and males and have identified four specific genes (MTND1P23, IGSF10, MSR1, and DUXAP9) that were differentially expressed in transgender females. Among these genes, macrophage scavenger receptor 1 was down-regulated 0.5- or 0.4-fold compared to cis females and cis males, respectively. Transient expression of MSR1 suppressed in vitro HIV infection, suggesting that MSR1 protects cells against HIV. The data indicate that down-regulation of MSR1 in transgender women may play a role in their increased HIV risk. Future studies on the mechanisms by which MRS1 inhibits HIV infection may offer new strategies for HIV prevention in transgender women.\n NIH R21AI55322","PeriodicalId":22698,"journal":{"name":"The Journal of Immunology","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4049/jimmunol.210.supp.75.44","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Transgender people are at greater risk than cisgender people of acquiring HIV and other sexually transmitted infections. Globally, the risk of acquiring HIV infection is nearly 49 times higher in transgender women than in other populations. Although behavioral and psychosocial factors contribute to the higher HIV risk in transgender people, gender-affirming hormone (GAH) (i.e., testosterone for transgender individuals assigned female at birth or estrogen/antiandrogen for transgender individuals assigned male at birth) may alter immune cell functions, resulting in increased HIV transmission. We have profiled gene expression of PBMCs from transgender females and males and have identified four specific genes (MTND1P23, IGSF10, MSR1, and DUXAP9) that were differentially expressed in transgender females. Among these genes, macrophage scavenger receptor 1 was down-regulated 0.5- or 0.4-fold compared to cis females and cis males, respectively. Transient expression of MSR1 suppressed in vitro HIV infection, suggesting that MSR1 protects cells against HIV. The data indicate that down-regulation of MSR1 in transgender women may play a role in their increased HIV risk. Future studies on the mechanisms by which MRS1 inhibits HIV infection may offer new strategies for HIV prevention in transgender women. NIH R21AI55322
巨噬细胞清道夫受体1,HIV感染的抑制因子,在变性女性中下调
变性人比顺性人感染艾滋病毒和其他性传播疾病的风险更大。在全球范围内,跨性别妇女感染艾滋病毒的风险比其他人群高出近49倍。虽然行为和社会心理因素导致跨性别者感染艾滋病毒的风险较高,但性别确认激素(即,出生时被指定为女性的跨性别者的睾丸激素或出生时被指定为男性的跨性别者的雌激素/抗雄激素)可能改变免疫细胞功能,导致艾滋病毒传播增加。我们分析了跨性别女性和男性的PBMCs基因表达,并确定了四个特定基因(MTND1P23、IGSF10、MSR1和DUXAP9)在跨性别女性中差异表达。在这些基因中,巨噬细胞清道夫受体1分别比顺性雌性和顺性雄性下调0.5倍或0.4倍。MSR1的瞬时表达抑制了体外HIV感染,表明MSR1保护细胞免受HIV感染。这些数据表明,跨性别女性中MSR1的下调可能与她们增加的艾滋病毒风险有关。未来对MRS1抑制HIV感染机制的研究可能为跨性别女性的HIV预防提供新的策略。NIH R21AI55322
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信