Antihistaminic properties of local anesthetics and anesthetic properties of antihistaminic compounds.

Abstract

Abstract 1.1. The antihistaminic effect of procaine and Stovaine in the Dale bath was 0.01 of that of Benadryl. 2.2. Procaine hydrochloride intravenously injected immediately before an intravenous lethal or sublethal dose of histamine had no protective effect in guinea pigs. 3.3. Stovaine, with the same technique, protected guinea pigs against histamine death and had a slightly protective effect against anaphylactic shock. 4.4. Antihistaminic compounds had from 2 to 2.5 times as much anesthetic effect as procaine in the guinea pig skin wheal and from 2.4 to 4 times as much anesthetic effect as procaine in human skin.